Loratadine is a second-generation antihistamine that has selectivity for peripheral H1 receptors, this drug is non-sedative because it is not able to cross blood-brain barrier. Loratadine shows its antihistaminic activity by inhibiting H1-receptors located on vascular endothelial cells, respiratory smooth muscle cells, the gastrointestinal tract, and immune cells.
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Uses
Loratadine is utilized for the following therapeutic indications:
- Alleviating symptoms of allergic rhinitis, such as sneezing, runny or itchy nose, and itchy or watery eyes
- Providing relief from skin hives and itching in patients with chronic skin reactions
- Managing symptoms of seasonal allergies





