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Generics

Hydroxychloroquine Sulphate

Used For

Rheumatoid Arthritis

How it works

Hydroxychloroquine exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.

Usage And Safety

Dosage

Active Rheumatoid Arthritis Adults: A suitable initial dose of Hydroxychloroquine sulfate is 400mg to 600mg (2 or 3 tablets) daily, preferably taken at meal times. Four to twelve weeks therapy is required before the effect of treatment can be evaluated. Lupus Erythematosus : The dose of Hydroxychloroquine sulfate depends on the severity of the disease and the patient’s response to treatment.Adults: An initial recommended dose of Hydroxychloroquine sulfate is 400-800mg daily. This level can be maintained for several weeks and then reduced to a maintenance dose.Maintenance dose: Doses are reduced to the minimum effective dose for maintenance that is 200-400mg daily but should not exceed 6.5mg/kg body weight daily (or 400mg daily whichever is smaller). To avoid excessive dosage in obese patients, special care is needed to calculate the dosage on the basis of lean body weight.Children: The minimum effective dose should be used upto a maximum of 6.5mg/kg body weight daily (or 400mg daily whichever is smaller). OR As directed by your physician.

Side Effects

The side-effects of hydroxychloroquine includes gastro-intestinal disturbances, headache and skin reactions (rashes, pruritus); those occurring less frequently include convulsions, visual changes, keratopathy, ototoxicity, hair depigmentation, hair loss and discoloration of skin, nails, and mucous membranes. In rare cases, hydroxychloroquine has caused visual changes or loss of vision. Side-effects that occur rarely include blood disorders (including thrombocytopenia, agranulocytosis and aplastic anemia), mental changes (including emotional disturbances and psychosis), myopathy, (including cardiomyopathy and neuromyopathy), acute generalized exanthematous pustulosis, exfoliative dermatitis, Stevens-Johnson syndrome, photosensitivity and hepatic damage, angioedema has also been reported.

Drug Interactions

Alfa and Beta Agalsidase , Laronidase , Amiodarone , Droperidol , Moxifloxacin , Antacids , Kaolin , Lanthanum , Antiepileptic , Mefloquine , Ciclosporin , Digoxin , Cimetidine , Neostigmine , Pyridostigmine .

Indication

Hydroxychloroquine sulfate is indicated for the treatment of: * Active rheumatoid arthritis (including juvenile idiopathic arthritis). * Systemic and discoid lupus erythematosus. *Dermatological conditions caused or aggravated by sunlight.

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