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Categories: Brand:

Generics

Omeprazole

Used For

Gastroesophageal Reflux Disease

How it works

It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), the proton pump of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Usage And Safety

Dosage

Symptomatic gastro-esophageal reflux disease (GERD) without esophagitis: The recommended adult oral dose is 20mg daily for up to 4 weeks. Erosive esophagitis: The recommended adult oral dose for the treatment of patients with erosive esophagitis and accompanying symptoms due to GERD is 20mg daily for 4 to 8 weeks. Maintenance of healing of erosive esophagitis: The recommended adult oral dose is 20 mg daily . Dosage for children in GERD: In children, doses in the ranges 0.7 to 1.4mg per kg body weight daily, up to a maximum daily dose of 40mg have been given for 4 to 12 weeks. Gastric and duodenal ulcer: A single daily dose of 20mg by mouthor 40mg in severe cases is given. Treatment is continued for 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer. Where appropriate, a dose of 10mg to 20mg once daily may be given for maintenance. OR As directed by your physician.

Side Effects

Common : Central and peripheral nervous system: Headache. Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting and flatulence.Uncommon : Central and peripheral nervous system: Dizziness, paraesthesia, somnolence, insomnia and vertigo.Hepatic: Increased liver enzymesSkin: Rash and/or pruritis, urticariaOther: MalaiseRare : Central and peripheral nervous system: Reversible mental confusion, agitation,aggression, depression and hallucinations, predominantly in severely ill patients.Endocrine: Gynecomastia

Drug Interactions

Ketoconazole and itraconazole , diazepam, citalopram, imipramine, clomipramine, phenytoin , Atazanavir , Digoxin , Clopidogrel , posaconazole, erlotinib , Saquinavir , Tacrolimus , Methotrexate , clarithromycin , CYP2C19 or CYP3A4 or both (such as rifampicin and St John’s wort.

Indication

It (Omeprazole) is indicated in adults for the treatment of: Gastro-Esophageal Reflux Disease (GERD):- Treatment of erosive reflux esophagitis.- Long term management of patients with healed esophagitis to prevent relapse.- Symptomatic treatment of gastroesophageal reflux disease (GERD).

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