Generics
Sertraline HCl
Used For
Depression
How it works
Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT).
Usage And Safety
Dosage
Dosage in Patients with MDD, OCD, PD, PTSD, and SAD : A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage. For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. Always consult your doctor or pharmacist for dose adjustment.
Side Effects
Hypersensitivity reactions to sertraline , Disulfiram-alcohol reaction when ZOLOFT oral solution is taken with disulfiram , QT prolongation and ventricular arrhythmias when taken with pimozide , Suicidal thoughts and behaviors , Serotonin syndrome , Increased risk of bleeding , Activation of mania/hypomania , Discontinuation syndrome , Seizures , Angle-closure glaucoma , Hyponatremia.
Drug Interactions
Selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue , other SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John’s Wort, aspirin, clopidogrel, heparin, warfarin , propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thoridazine, tolterodine, venlafaxine , fosphenytoin .
Indication
Sertraline HCl is indicated for the treatment of the following *Major depressive disorder (MDD) * Obsessive-compulsive disorder (OCD) * Panic disorder (PD)




