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Generics
Dapagliflozin
Used For
Diabetes
How it works
Sodium-glucose cotransporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Dapagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, dapagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion.
Side Effects
Infections and infestations : Common: Vulvovaginitis, balanitis and related genital infections, Urinary tract infection (including pyelonephritis and urosepsis) Uncommon: Fungal infection Metabolism and nutrition disorders . Very common: Hypoglycaemia (when used with sulphonylurea or insulin) Uncommon: Volume depletion, Thirst Rare: Diabetic ketoacidosisNervous system disorders : Common: DizzinessGastrointestinal disorders
Drug Interactions
ACE inhibitors , Flouroquinolones , Somatostatin Analogues , SGLT2 inhibitors
Indication
It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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