Generics
Duloxetine hydrochloride
Used For
Depression
How it works
Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.
Usage And Safety
Dosage
Adults : Major drepressive disorder : Initial & maintenance dose : 60mg once daily. Generalized anxiety disorders : 30mg daily, increased if necessary to 60mg once daily , max 120mg daily. Diabetic peripheral neuropathic pain : 60mg once daily , max 120mg in divided doses. Children : Not recommended. OR As directed by your physician.
Side Effects
GI disorders , excessive sweating CNS disorders e.g. dizziness , fatigue , insomnia , somnolence , blurred vision , dysuria , headache , dry mouth , wt loss , palpitation , tremor , tinnitus , muscle spasms , anorexia, increased libido , anxiety , abnormal dreams.
Drug Interactions
CYP1A2 Inhibitors , CYP2D6 Inhibitors , tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazine and Type 1C anti-arrhythmic (e.g., propafenone, flecainide), Alcohol.
Indication
It is used in depression, anxiety, neuropathic and muscular pain.




