Requires Prescription (YES/NO)
Yes
Generics
Midazolam
Used For
Anesthesia
How it works
It is a short acting benzodiazepine, used as a premedicament and sedative in surgical procedures and for the induction of anaesthesia. Onset time of sedative effects after IM administration is 15 minutes with peak sedation occurring in 30-60 minutes
Usage And Safety
Dosage
Standard dosage : Midazolam is a potent sedative agent which requires slow administration and individualization of dosage. The dose should be individualized and titrated to the desired state of sedation according to the clinical need, physical status, age and concomitant medication. Preoperative/preprocedural sedation : Healthy adults <60yr : IM : 0.07-0.08mg-kg 30-60 minutes prior to surgery / procedure , usual dose 5mg . IV : 0.02-0.04mg/kg , repeat every 5 minutes as needed to desired effect or upto 0.1-0.2mg/kg . Conscious sedation : IV : Healthy adults <60 yr : Initial 1mg ; no more than 2.5mg over a period of 2 minutes . Total dose above 5mg is generally not needed . Maintenance 25% of dose used to reach sedative effect OR As directed by your physician .
Side Effects
Fluctuations in vital signs including decreased respiratory effects, variation in blood pressure and pulse rate are the most frequently seen findings. Laryngospasm, bronchospasm, dyspnoea, hyperventilation and airway obstruction.Premature ventricular contraction, vasovagal episode and tachycardia.Retrograde amnesia, euphoria, confusion, nervousness, restlessness, nightmares dysphonia and paresthesia.Blurred vision, diplopia, nystagamus, visual disturbances, blocked ears, loss of balance and light headedness.Headache, hiccough, nausea, vomiting, yawning, lethargy, weakness and faint feeling.
Drug Interactions
Antipsychotics , hypnotics , antidepressants , narcotic analgesics , anticonvulsants , anesthetics , antihistamines , alcohol, erythromycin , cimetidine , diltiazem , verapamil , ketoconazole , fluconazole , itraconazole , cyclosporin , nifedipine , nabilone , muscle relaxants , ulcer healing drugs , xanthines , macrolides , protease inhibitors.
Indication
For induction of general anaesthesia. For preoperative sedation (induction of sleepiness and relief of apprehension) and also to impair memory of preoperative events .
When not to Use
It is contra-indicated in patients with known hypersensitivity to the drug. Benzodiazepines are contraindicated in patients with acute narrow angle glaucoma.
Precautions
Precaution
Infants and children younger than 3 years using anesthesia or drugs for sedation (including midazolam) for procedures/surgeries may be at risk for slower brain growth. Talk to the doctor about the risks and benefits of this medication.
Warnings
Warning 1
Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain eye problems (narrow-angle glaucoma, untreated open-angle glaucoma), heart failure, kidney disease, liver disease.
Warning 2
Do not take prescription medications , OTC sedatives or hypnotics for atleast 24 hours after administration.
Warning 3
This medication is not recommended for use during pregnancy. It may harm an unborn baby.
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.




